Zimbabwe’s Ministry of Health initiated the Isoniazid preventive programme (IPT) in stages from January 2012, but implementation progressed slowly. Expanding tuberculosis preventive therapy (TPT), including IPT, is crucial for the healthcare system. Scarce research on IPT programme implementation and monitoring in Mashonaland East’s health centres prompted this study.

Using the logic model framework, a process-outcome evaluation of Ruwa Hospital’s IPT programme was conducted. Forty healthcare workers underwent assessment of their IPT knowledge, while key informants provided insights into the programme’s operations.

The results revealed a well-managed IPT programme, staffed with knowledgeable nurses and doctors. While TB and HIV/Aids guidelines were sufficient, the availability of Isoniazid 100mg fluctuated. Formal training for healthcare workers on IPT was irregular, compensated partially through knowledge sharing in departmental meetings. Adequate support and supervision structures were evident, alongside regular institutional and community sensitisation. However, there was a lack of information, education and communication materials for public distribution. Despite the programme’s success, improvements were advised, including ensuring consistent medication availability and organising regular formal training for healthcare workers.