Pharmacovigilance (PV) and reporting adverse drug reactions (ADRs) play a vital role in the antiretroviral therapy (ART) programme, offering evidence-based insights into medication toxicity, bolstering medication safety and mitigating patient exposure to such risks. The ART programme’s efficacy hinges significantly on the consistent implementation of these measures.

Healthcare professionals (HCPs) are pivotal in PV and ADR reporting. This study assessed HCPs’ knowledge, attitudes and practices regarding PV and ADR reporting, conducted across nine ART public healthcare facilities in Francistown, Botswana, from May to June 2022, employing an online questionnaire.

The findings revealed that while 96,55% of HCPs demonstrated a correct understanding of PV, only 60% could define an ADR. Although 96,66% were aware of the ADR reporting form, only 53,3% reported ADRs using the proper form. Most participants viewed ADR reporting as part of their duty, disagreeing that it added undue workload. While HCPs exhibited adequate knowledge of and positive attitudes to PV and ADR reporting, actual reporting practices were deficient.